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Less common side effects may include nausea, dizziness, rash, increased urination, and diarrhea. In rare cases, Generic Viagra may cause an erection that lasts longer than 4 hours. Other rare side effects may include an irregular heartbeat, chest pain, and sudden vision loss. Viagra contains the active ingredient sildenafil which is available as a generic medication. Often called the little blue pill, it works by improving blood flow to your penis, making it easier to get an erection hard enough for sex. It’s one of the most effective ED treatments available, working for up to 74% of men who take it.
To get the maximum benefit from your medication, it is advisable not to drink excessive amounts of alcohol before taking this medication. A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates). The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP.
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