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Manufacture and sale of sildenafil citrate drugs is common in China, where Pfizer's patent claim is not widely enforced. Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.
The NHS states that there’s no clear evidence that taking Viagra affects fertility of men or women. Further studies need to be carried out to determine a link between Viagra and fertility. While a beer or a couple of glasses of wine won’t affect how Viagra works, any more than this can make it harder to get an erection. It’s advised to not drink heavily before taking Viagra if you would like the best results.
Both sildenafil and the metabolite have terminal half lives of about 4 hours. Studies have produced relevant data on the effects of VIAGRA on cardiac output. In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. A total dose of 40 mg sildenafil was administered by four intravenous infusions.
(This is especially true if you eat a high fat meal with your dose.) If your indigestion is bothersome, ask your doctor or pharmacist to recommend medication to help reduce your discomfort. If you have low blood pressure, taking Viagra could make you feel dizzy or lightheaded, or cause you to faint. You’re also more likely to have these problems if you take Viagra with certain drugs used to treat high blood pressure or enlarged prostate.
Physicians should advise patients of the potential for VIAGRA to augment the blood pressure lowering effect of alpha-blockers and anti-hypertensive medications. Concomitant administration of VIAGRA and an alpha-blocker may lead to symptomatic hypotension in some patients. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.
If you have diabetes or heart conditions like atherosclerosis (fat buildup in blood vessels), do expect Viagra to be less effective and last for a shorter duration. If possible, limit alcohol consumption or smoking before taking Viagra as they decrease blood flow to the penis, thereby reducing the Viagra’s overall effectiveness. Certain medications (such as those including nitrates or alpha-blockers) can interact with Viagra, affecting how long the Viagra lasts in your system. In such cases, you might require different dosages of Viagra for better results. However, the duration of Viagra’s effects depend on various external factors such as your body’s metabolism rate. For most men, Viagra lasts between 2 to 3 hours before its effects start decreasing.
Ideally, you should take Viagra about 30–60 minutes before sex for maximum effect. Remember, it won't give you an erection if you are not already sexually aroused. The highest available dose of sildenafil is 100 mg, but that doesn't mean it's the right dose for you.
Additionally, SILDENAFIL may also be used to treat pulmonary arterial hypertension (high blood pressure in the lungs) in adults to improve the ability to exercise and to slow down clinical worsening. SILDENAFIL works by relaxing the blood vessels in the penis, thereby allowing the blood to flow into the penis when the person is sexually excited. SILDENAFIL relaxes the blood vessels, increases the blood supply to the lungs and reduces the workload of the heart. You are advised to take SILDENAFIL for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, SILDENAFIL may cause side effects such as headache, nausea, dizziness, indigestion and stomach upset.
If this occurs, it’s usually within 1–2 hours after taking it. When PDE5 inhibitors like Viagra are used to treat erectile dysfunction, these medications work by widening the blood vessels, thus, increasing blood flow into the penis. Notably, the effects of Viagra only occur in the presence of sexual stimulation.
The highest available Viagra dosage is 100 mg, but that doesn’t mean 100 mg is suitable for you. When it comes to medication, more isn't always better (or more effective). Like any medication, Viagra comes with potential risks, side effects, and contraindications.
Before you can begin to treat your FSD, you first need to understand what’s behind it. A lot of the time, FSD is caused, or aggravated, by the menopause, mental health problems and relationship issues. Getting to the root of your FSD should help you find a safe and effective treatment.
In order for VIAGRA to be effective, sexual stimulation is required. And it hasn’t been studied in people who are breastfeeding. Viagra may pass into breast milk, but it’s not known if this could affect a breastfed child. It’s unknown whether this drug is safe to take during pregnancy.
Thus, making erections easier to achieve and maintain if you are sexually aroused. If you are considering using generic Viagra, it is important to consult with your doctor first. Your doctor can provide you with information on potential side effects and other important considerations. Additionally, it is important to follow the directions provided by your doctor when taking generic Viagra. This includes taking the medication as prescribed, making sure to take it at the same time every day, and always discussing any new medications with your doctor.
You will be charged for the online visit as soon as it is approved by the healthcare practitioner. From there, and after your prescription is activated by the pharmacy, you will be charged the medication cost for each shipment based on your chosen refill schedule. If you have provided insurance or benefits coverage details, it will be applied according to your plan. Felix is Canada’s first truly integrated healthcare platform. We provide on-demand treatment for everyday health needs like weight loss, mental health, sexual health, and more.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Do not use more of it and do not use it more often than your doctor ordered. If too much is used, the chance of side effects is increased.
Sometimes a lower starting dose of 25mg will be suggested by a clinician. This route may be considered if you’re already taking certain medications for the treatment of kidney, liver or heart conditions. Or if your previous tolerance of sildenafil citrate 50mg was low.
The results showed that sildenafil is effective in the treatment of erectile dysfunction in this group of patients. Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex.
But your doctor might prescribe a lower starting dosage of 25 mg depending on several factors. A review of population subgroups demonstrated efficacy regardless of baseline severity, etiology, race and age. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction (80 mg t.i.d.) resulted in a 50% increase in AUC and a 42% increase in Cmax of bosentan (125 mg b.i.d.). The most common adverse reactions reported in clinical trials (≥ 2%) are headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, and rash. VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking anti-hypertensive medications.
Private Prescription medicines are not eligible for a government PBS subsidy. The full cost of the prescribed medicine is covered by the patient. The cost of which may be claimed from private health insurance providers depending on the level of cover. Healthylife Pharmacy will provide an official receipt for private prescription items to facilitate eligible claims. The half-life of Viagra is four hours—which means in four hours, half of the drug will be eliminated from the body.
Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs.
He has helped Fortune 500 executives, Olympic athletes, top trainers, and A-list celebrities optimize their health, recover faster from injury, and improve their sports performance. Having a satisfactory sex life is important for many people, and getting older doesn’t have to mean the end of this aspect of your life. If you and your partner prioritize sex but are experiencing roadblocks with ED symptoms, know that you’re not alone and help is available. The value of ED treatments includes the initial cost, long-term financial implications, and overall cost-effectiveness.
Avoid consumption of alcohol as it may impair your ability to get an erection. Taking SILDENAFIL after a heavy meal might take longer time for the medicine to work