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Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil. Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach. In the second study, a single oral dose of VIAGRA 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH. Following at least 14 consecutive days of doxazosin, VIAGRA 50 mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects). In the first study, a single oral dose of VIAGRA 100 mg or matching placebo was administered in a 2-period crossover design to 4 generally healthy males with benign prostatic hyperplasia (BPH).
VIAGRA 100MG is a trusted and effective solution for men experiencing erectile dysfunction, helping to restore confidence and improve sexual health. Always follow the advice of your healthcare professional for the best results. The main difference between sildenafil and Viagra is that Viagra is branded, and sildenafil is the generic, or unbranded, version of it. As both sildenafil and Viagra contain the same active ingredient, sildenafil citrate, they are both effective treatments for men with ED. All generic medication has to contain the same active ingredient to ensure it works in the same way as its brand-name equivalent. Felix charges a fee for the online visit, but only if and when you are approved by the healthcare practitioner.
The orodispersible tablets should be placed on the tongue and left to disintegrate before swallowing. Sildenafil 50mg is the recommended starting dose for most men with erectile dysfunction (ED). It is effective for most men and has a lower risk of side effects than sildenafil 100mg. Other than erectile dysfunction, Viagra is also used for treating a condition called pulmonary hypertension (high blood pressure in the lungs). This condition may require you to take Viagra daily, but the dosage, in this case, is different. Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products.
Episodes of spasm can be triggered by cold temperatures or stress. In addition to the use described above, Viagra may be used off-label. Off-label drug use is when a drug that’s approved for one condition is given for a different condition that’s not approved.
Structurally vardenafil (Levitra 40 mg) is similar to sildenafil, while tadalafil (Cialis) is very different. Vardenafil (Levitra) is almost 10 times more biochemically potent than sildenafil, therefore a lower dose is needed to facilitate the penile erection, potentially resulting in less side effects. Selectivity is the ability of the drug to attach to the specific enzyme PDE 5 found in penile tissues. Vardenafil (Levitra) is more selective than sildenafil and tadalafil (Cialis) to PDE5, which again means a lower dose is needed with potentially less side effects. Tadalafil is very specific for PDE5 and is also very specific for the enzyme PDE11. Unfortunately, we don’t know much about PDE11, which is found in the heart, in the pituitary gland in the brain and in the testicles.
After taking a dose of Viagra, the drug’s level in your body will gradually decrease over a period of a few hours. You’ll have low levels of the drug in your body after about 4 hours. (And at this point, the drug won’t be working any longer.) But it can actually take about 24 hours for Viagra to be completely removed from your body. Even though Viagra keeps working in your body for several hours, your erection shouldn’t last this long. In fact, in rare cases, Viagra can cause priapism (a long-lasting and sometimes painful erection). Remember, you should not change your dosage of Viagra without your doctor’s recommendation.
Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Dosage adjustments are not required in elderly patients (≥ 65 years old). If you have questions about the safety of using Viagra while breastfeeding, talk with your doctor. If you have questions about the safety of Viagra use during pregnancy, talk with your doctor. Viagra tablets should be stored at room temperature between 68oF and 77°F (20oC and 25°C).
Viagra belongs to a class of medications called phosphodiesterase-5 (PDE-5) inhibitors. It works by temporarily increasing the blood flow to your penis, helping you to get and maintain an erection. Regarding which medication allows an erection to last longer, the clear winner is tadalafil. Sildenafil remains effective for four to six hours, while tadalafil will enable patients to achieve erections up to 36 hours after ingestion, an effect usually seen in younger patients or lesser degrees of ED. In both cases, the drug does not increase desire, instead allowing for a better erection when the desire is present. The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.
The Food and Drug Administration (FDA) considers generics to be just as safe and effective as the original drug. This means that generic sildenafil is just as effective in treating ED as Viagra is when it’s taken at the same doses as Viagra. It also means that sildenafil and Viagra can cause the same side effects.
Then, if this dosage isn’t correct for you, you can change it to a different dosage. Many people who take Spedra do not experience any side effects at all. However, if you have never taken this ED medication before, or if you take the stronger 200mg dosage of Spedra, you are more likely to experience side effects. A visit with a licensed healthcare practitioner is required for all treatments currently provided through Felix’s service. You can expect to receive a response from a healthcare practitioner within 24 hours of submission.
Although most ED medications are rigorously tested, studied, and approved before reaching drug stores, they all come with a risk of side effects. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Sildenafil and Viagra tablets both have the same side effects, do not take more than one each day and do not take both at the same time. The main difference between Sildenafil and Viagra tablets is price, Viagra tablets are expensive in comparison. This is due to Viagra tablets being branded, whereas Sildenafil is the generic medication but works in the exact same way.
Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see Drug Interactions (7.4) and Clinical Pharmacology (12.3)]. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, cimetidine). Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Most, but not all, of these patients had pre-existing cardiovascular risk factors.
Viagra may not work the first time for everyone, so making sure you’re sexually aroused will increase the probability of it working for you. Once it does start to work, you can expect its effects to last up to 3 or 4 hours. An erection should never last more than 4 hours—if it does, seek medical help. Levitra is an erectile dysfunction treatment, which contains the active ingredient vardenafil. All drug manufacturers