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The mean absolute oral bioavailability is 41% (range 25-63%). After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range ( mg). No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Cimetidine (800 mg), a cytochrome P450 inhibitor and non-specific CYP3A4 inhibitor, caused a 56% increase in plasma sildenafil concentrations when co-administered with sildenafil (50 mg) to healthy volunteers. Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to 100 mg as necessary.
They will probably encourage you to try it a few more times before you move onto something else. If you are having trouble getting and keeping erections, it’s important to speak to a doctor. Erectile dysfunction can be a sign of a serious health issue. You can learn more about the side effects of Viagra online or read about them in the patient leaflet that comes with the medication. Generic versions, such as sildenafil, are available on the NHS to treat erectile dysfunction.
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