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Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see Drug Interactions (7.4) and Clinical Pharmacology (12.3)]. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, cimetidine). Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Most, but not all, of these patients had pre-existing cardiovascular risk factors.
The orodispersible tablets should be placed on the tongue and left to disintegrate before swallowing. Sildenafil 50mg is the recommended starting dose for most men with erectile dysfunction (ED). It is effective for most men and has a lower risk of side effects than sildenafil 100mg. Other than erectile dysfunction, Viagra is also used for treating a condition called pulmonary hypertension (high blood pressure in the lungs). This condition may require you to take Viagra daily, but the dosage, in this case, is different. Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products.
Figure 6 shows that regardless of the baseline levels of function, subsequent function in patients treated with VIAGRA was better than that seen in patients treated with placebo. At the same time, on-treatment function was better in treated patients who were less impaired at baseline. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC).
Thankfully, Felix is making it quick and seamless for Canadians to access sildenafil online. Just complete an online assessment, and if your practitioner believes it’s right for you, they can provide you with a sildenafil prescription. During your online visit you'll be asked for information about your health history for the doctor to review. Your Felix doctor will use this information to determine safety and potential side effects. Your healthcare practitioner will build a personalized plan just for you.
You should read the patient information leaflet supplied with your medication, for a full list of ingredients. If the 50mg tablets are not working well for you, your doctor or pharmacist may increase the dose to 100mg. Your doctor or pharmacist may also suggest that you try sildenafil 25mg tablets if you are experiencing side effects with the 50mg tablets. Very common &